14,17α-etheno- and -ethanoestratrienes, processes for the preparation of these compounds, as well as their use for the production of medicinal agents

US-55834090-A
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(en)Disclosed are novel 14,17α-etheno- and -ethanoestratrienes according to general Formula I ##STR1## wherein X is a --CH 2 --CH 2 or ##STR2## R 1 is a hydrogen atom, a C 1 - to C 15 -acyl, benzoyl, C 1 - to C 15 -alkyl, C 3 - to C 9 -cycloalkyl or alkylcycloalkyl group, and
R 2 is the grouping ##STR3## wherein R 3 and R 4 independently of each other mean a hydrogen atom or a straight-chain or branched, optionally partially or completely fluorinated C 1 -C 8 -alkyl group,
a process for their preparation, pharmaceutical preparations containing these compounds, as well as their use for the production of medicinal agents.
The novel compounds exhibit strong antiestrogenic efficacy.

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