Activation of HCV-specific T cells

US-35761903-A
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Nationwide
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(en)The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4 + and CD8 + T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5 a, and NS5 b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of these fusions. The method can be used in model systems to develop HCV-specific immunogenic compositions, as well as to immunize a mammal against HCV.

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