Acyclic oximyl hepatitis c protease inhibitors

US-75890107-A
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Nationwide
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(en)The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof:









which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

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